Reticulate acropigmentation of Kitamura
| Reticulate acropigmentation of Kitamura | |
|---|---|
| Other names: RAK[1] | |
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| Reticulate hyperpigmentation on: a) Dorsa of both hands b) Dorsa of both feet c) Neck d) Axilla | |
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| Specialty | Dermatology |
| Symptoms | Colored freckle-like and slightly depressed spots arranged in a lace-like pattern on the backs of hands and feet[2] |
| Usual onset | Adolescence and young adults[2] |
| Causes | Autosomal-dominant[2] |
| Differential diagnosis | Dowling–Degos disease[2] |
| Frequency | Rare[2] |
Reticulate acropigmentation of Kitamura is a type of pigmentation disorder of the skin.[2] It presents with colored freckle-like and slightly depressed spots arranged in a lace-like pattern on the backs of hands and feet.[2] It tends to occur in skin folds of adolescents and early adulthood, and darkens over time.[2]
It is inherited in an autosomal-dominant fashion.[2]
The condition is rare.[2] It was first described in Japan, before recognising that is also occurs elsewhere.[2]
Genetics
This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.
See also
References
- ↑ "Orphanet: Reticulate acropigmentation of Kitamura". www.orpha.net. Archived from the original on 25 November 2020. Retrieved 23 April 2019.
- 1 2 3 4 5 6 7 8 9 10 11 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation: Reticulate acropigmentation of Kitamura". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 867. ISBN 978-0-323-54753-6. Archived from the original on 2022-08-13. Retrieved 2022-08-12.
External links
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