Anonychia

Anonychia
Anonychia
SpecialtyDermatology
SymptomsAbsent or small nails[1]
FrequencyRare[2]

Anonychia is the absence of finger or toe nails, such as in nail-patella syndrome.[1]

It may be the result of a congenital ectodermal defect, ichthyosis, severe infection, severe allergic contact dermatitis, self-inflicted trauma, Raynaud phenomenon, lichen planus, epidermolysis bullosa, or severe exfoliative diseases.[2] It can also occur in severe psoriasis.[1] It may occur on its own due to a mutation in the RSPO4 gene.[3]

It is rare.[2]

Congenital form

This is rare and is usually due to mutations in the R-spondin 4 (RSPO4) gene which is located on the short arm of chromosome 20 (20p13).[4] Clinically it is manifest by the absence (anonychia) or hypoplasia (hyponychia) of finger- or toenails.

Additional images

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    Anonychia
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    Anonychia
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    Anonychia
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    Anonychia

See also

References

  1. 1 2 3 MacGilchrist, Claire (2020). "3. The skin and nails in podiatry". In Burrow, J. Gordon; Rome, Keith; Padhiar, Nat (eds.). Neale's Disorders of the Foot and Ankle (9th ed.). Elsevier. p. 52. ISBN 978-0-7020-6504-0. Archived from the original on 2023-01-06. Retrieved 2022-04-15.
  2. 1 2 3 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "33. Diseases of the skin appendages". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 782. ISBN 978-0-323-54753-6. Archived from the original on 2022-04-15. Retrieved 2022-04-14.
  3. ↑ Bellet, Jane Sanders (2021). "Paediatric nail disorders". In Lipner, Shari (ed.). Nail Disorders: Diagnosis and Management, An Issue of Dermatologic Clinics. Philadelphia: Elsevier. pp. 232–233. ISBN 978-0-323-70923-1. Archived from the original on 2022-07-03. Retrieved 2022-07-01.
  4. ↑ Khan TN, Klar J, Nawaz S, Jameel M, Tariq M, Malik NA, Baig SM, Dahl N (2012) Novel missense mutation in the RSPO4 gene in congenital hyponychia and evidence for a polymorphic initiation codon (p.M1I). BMC Med Genet 13(1):120
Classification


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