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I have a RAMPS 1.4 with Arduino Mega 2560 with 2 steppers connected to an external power supply using Polulo stepper drivers. The steppers are for X and Y axis movement. This external power supply is set to 12 volts and power is applied. I have configured the marlin firmware also.

Can I connect my setup to my PC using USB when the external power is also on? If i connect the USB while the external power is off, do the motors take power from USB? Will this will burn my board?

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Can I connect my setup to my PC using USB when the external power is also on? As long as you are connecting the external power to the correct pins, yes you can.

If i connect the USB while the external power is off, do the motors take power from USB? No, the motors need an external power supply.