prehepatic

pre- +‎ hepatic

prehepatic (not comparable)

1. (anatomy) anterior to the liver.
2. (anatomy, biochemistry) upstream of the liver in the circulation of the hepatic portal system; and thus, before the metabolic effect of the liver.
   • 2015 June 12, Jeanne Mendell et al., “The Effect of Rifampin on the Pharmacokinetics of Edoxaban in Healthy Adults”, in Clinical Drug Investigation‎, volume 35, DOI:10.1007/s40261-015-0298-2:

     Administration of intravenous edoxaban with and without rifampin may have differentiated the prehepatic versus hepatic effects of rifampin on parent and metabolite exposure.

• posthepatic