Royan Institute

Royan Institute (Persian: پژوهشگاه رویان) is an Iranian clinical research and educational institute dedicated to biomedical, translational and clinical research, stem cell research, and infertility treatment. It is a public non-profitable organization affiliated to Academic Center for Education, Culture, and Research.[1] It was established in 1991 by the late Dr. Saeid Kazemi Ashtiani[2][1] as a research institute for Reproductive Biomedicine and infertility treatments. In 1998 this institute was approved by the Ministry of Health as Cell-Based Research Center with over 46 scientific members and 186 lab technicians. Iran ranks second in the list of countries where stem cell research is popular.[3]

Royan Institute
پژوهشگاه رویان
TypeResearch Institute
EstablishedMay 29, 1991 (1991-05-29)
FounderDr. Saeid Kazemi Ashtiani
AffiliationAcademic Center for Education, Culture and Research
PresidentProf. Abdolhossein Shahverdi
Location
Tehran and Isfahan
,
Iran

35°45′21″N 51°28′04″E
CampusUrban
LanguagePersian / English / French
Colors 
WebsiteOfficial website

history

Stem cell research in Iran began on a high note after the leader Ali Khamenei Emphasized on this type of research in 2002. Unlike the United States, which has discussed using human embryos in stem cell research, Iran has not encountered such obstacles. Iran has been able to make great progress in the 14 years of its research activity in this field.[3][4]

Research institutes

Royan consists of three research institutes, each focused on different fields of research:

  • Royan Institute for Stem Cell Biology and Technology (RI-SCBT)
  • Royan Institute for Reproductive Biomedicine (RI-RB)
  • Royan Institute for Developmental Biotechnology (RI-AB)

The institute has had close collaborations with other leading Iranian research centers such as Institute of Biochemistry and Biophysics[5] (IBB), NRCGEB, and the Hematology-Oncology and Stem Cell Transplantation Research Center at Shariati Hospital in Tehran.

Royan publishes the Cell Journal with an impact factor of 3.128 (2022).[6]


Royan Institute for Stem Cell Biology and Technology

Royan Institute for Stem Cell Biology and Technology (RI-SCBT)[7] first, as the "Department of Stem Cells," was established in 2002 to advance research on biology and technology of embryonic stem cells, induced pluripotent stem cells, germ line stem cells, adult stem cells, cancer stem cells, and cord blood stem cells.

The institute provides a comprehensive and coordinated "bench to bedside" approach to regenerative medicine, including a greater understanding of the fundamental biology of stem cells, developmental biology, tissue engineering programs, the development of translational research of stem cell therapeutics, and administration of new cell therapies approach that can restore tissue function to patients.

The RI-SCBT comprises four departments including the Department of stem cells and developmental biology,[8] the Department of cell engineering,[9] the Department of regenerative medicine,[10] and the Department of brain and cognitive sciences.[11]

Iran has some of the most liberal laws on stem cell research in the world. The institute founded a Department of Stem Cells in 2002 to establish human embryonic stem cell lines and Induced Pluripotent Stem Cell (iPSC), and to study differentiation into different kinds of cells including cardiomyocytes, beta cells, and neural cells. Researchers claimed a live birth of a cloned sheep in 2006, inviting foreign observers to verify the claim.[12]

Royan Institute for Reproductive Biomedicine

Royan Institute for Reproductive Biomedicine (RI-RB),[13] founded in 1991, consists of six departments and one clinic actively working on different aspects of infertility and the development of new methods for infertility treatment.

It aims to improve the population's health through infertility treatments and research different aspects of infertility and its treatment to increase the success rate alongside improving embryo health.

Royan Institute for Developmental Biotechnology

Developmental Biotechnology (RI-DB)[14] was initially established in 2004 as a research sub-institute that is located in Isfahan Province. The endeavors of RI-DB have made Royan Institute the pioneer of animal cloning in Iran and the Middle East. Coming up with the first cloned sheep in the Middle East in 2006 placed Iran among the few countries having this technology.[15] Making use of this technology in producing transgenic animals has led to bringing the goats into being in Isfahan and Tehran (2009) with the ability to secrete human coagulation factor 9 and human Tissue Plasminogen Activator (hTPA) in their milk.

The vision of RI-DB is to achieve high standards in biotechnology research and to make biotechnology a premier precision tool for future health development.

RI-DB includes the Animal Biotechnology department, three research groups, and four laboratories.

Chronological overview
  • 1993: The first IVF birth in Tehran[16]
  • 1995: The second ICSI birth in Iran[17]
  • 1996: Iran's second success in open testicular biopsy to treat severe male infertility[18]
  • 1996: The first frozen embryo birth in Iran[19]
  • 1999: The first ICSI birth by frozen sperm of a gonadectomized man[20]
  • 1999: The first celebration of the 1000th birth through assisted conception treatment in Iran[21]
  • 2003: The first human embryonic Stem Cell line establishment in Iran and the region[22]
  • 2003: Establishment of Stem Cells research department[23]
  • 2004: The first PGD child born in Iran[24]
  • 2004: The first time use of adult stem cells in the treatment of MI during CABG in Iran[25]
  • 2004: Production of insulin-producing cells from human embryonic stem cells.[1]
  • 2004: Culture of Human Limbal Stem Cells on Chorionic Membrane and use them for corneal injuries[26]
  • 2005: Establishment of the first Private Cord Blood Bank in Iran (Royan Stem Cell Technology Co.)[27]
  • 2006: The first IVM-IVF sheep born in Iran[28]
  • 2006: Iran's first cloned sheep, named Royana.[29]
  • 2006: The first nuclear transferred, in vitro fertilized sheep born[30]
  • 2007: Culture and transplantation of fibroblasts[31]
  • 2008: Establishment of mouse and human induced pluripotent stem cells (iPS)[32]
  • 2008: Transplantation of melanocytes for the patient with vitiligo[33]
  • 2009: The first cloned goat was born in Iran.[34]
  • 2010: The first transgenic goats born in Irans[35]
  • 2011: The first calves born from vitrified in vitro developed embryos in Iran[36]
  • 2011: Establishment of cell therapy pre-hospital[37]
  • 2011: Establishmentof Stem Cell Bank[38]
  • 2012: The first healthy childbirth after Molecular PGD for beta-thalassemia in Iran[39]
  • 2013: Birth of eight cloned goats through the simplified method of SCNT in Iran[40]
  • 2015: Birth of a cloned Isfahan mouflon to a surrogate domestic sheep.[41]
  • 2016: The first knock-in mice produced with CRISPR technology in Iran.[42]
  • 2017: The first transgenic zebrafish disease models in Iran.[43]
  • 2017: The first cryopreserved human ovarian tissue auto-transplantation in cancer patients.[44]
  • 2018: Establishment of the Faculty of Basic Sciences and Medical Technology in Royan Institute[45]
  • 2018: Establishment of the Advanced Therapy Medicinal Product Technology Development Center (ATMP)[46]
  • 2019: Obtaining the license to produce Kimia-cell in GMP conditions in Royan – ATMP Center from Iran FDA[47]
  • 2020: Producing the transgene Covid mouse for pre-clinical studies of Covid-19 vaccines[48]
  • 2020: Receiving the international ISO certificate; ISO 9001:2015 for Laboratory Animal Science Core Facility
  • 2021: Implementing the phase I clinical trial for Natural Killer cell therapy for pediatric glioblastoma[49]
  • 2022: Commercialization of human gamete and embryo freeze-thaw media[50]

Prominent achievements
  • Report of three new mutations of cystic fibrosis
  • Best paper selection in MEFS congress 2004
  • Best young researcher in Razi medical science award 2004[51]
  • Report of human embryonic stem cells’ proteomics for the first time in the world[52]
  • Registration of one human embryonic stem cell line in the International Society of Stem Cell Research[53]
  • Establishment of 6 human embryonic stem cell lines[54]
  • Establishment of 8 mouse embryonic stem cell lines which three of them can be donated to the centers or researchers for one time[55]
  • Introduction of late director of Royan Institute as Iran's everlasting legend in 2005
  • Best poster award in Stem Cell congress, India, 2005[56]
  • Selection as “prominent research center” in Razi medical sciences award[57]
  • Best researcher in Razi medical sciences award 2006[58]
  • Best medical journal (Cell Journal (yakhteh) ) in Razi medical sciences award 2006[59]
  • Best research achievement prize in Razi medical sciences award[60]
  • Best research achievement prize in Kharazmi young researcher award 2006
  • Best research prize in second international reproduction student award, Yazd, Iran, 2007[61]
  • Report of Mesenchymal stem cells’ new surface markers to the world
  • Publication of more than 3000 papers in local and international journals[62]
  • Performance of 341 research projects and follow of 225 undergoing projects
  • Presentation of 997 papers in national and international congresses
  • Publication of two journals: Cell Journal(Yakhteh) and IJFS (Iranian Journal of Fertility and Sterility), Indexed in ISI[63][64]
  • Editorial board of four internationals
  • six chapters of international textbooks in stem cell fields
  • Publication of more than 100 books
  • Performance of more than 56 inter-center and multi-center research nationally or internationally
  • Use of adult stem cells in corneal injuries and myocardial infarction on human[65]
  • Transplantation of stem cells to the animal model of diseases in hepatic cirrhosis, spinal cord injuries, bone defects, cartilage damage, and diabetes[66]
  • Several research achievements in preimplantation diagnosis and screening[67]
  • Producing iPS cell line, Royan H7[68]
  • Registration of T338A, K536X, Y122H genes in CBAVD (Congenital Bilateral Absence of Vas Deferens) patients, 2007[69]

Honors


  • 2004: Honoring the Everlasting Personage Prize[70]
  • 2009: Being selected by Iran National Award for the Book of the Year[71]
  • 2010: Receiving The Islamic Educational, Scientific, and Cultural Organization “ISESCO”- Science and Technology Prize[72]
  • 2012: Earning the scientific Hippocrates Prize
  • 2014: Winning the UNESCO Prize[73]
  • 2014: Winning Allameh Tabatabaei Award hosted by Iran vice Presidency for Science and Technology, Presidency and National Elite Foundation[74]
  • 2019: Earning The World Academy of Science “TWAS” Prize[75]
  • 2019: Gaining the 32nd Khawrizmi Award[76]
  • 2019: Receiving the Mustafa Prize[77]
  • 2020: Placing as one of the top ten research institutes worldwide during the last two decades according to the total number of publications in the field of male infertility and assisted reproductive techniques (ART)[78]
  • 2021: Receiving the Health Service Medal from Tehran Municipality, Health Section
  • 2022: Achieving second place among 52 Iranian Research Institutes
  • 2022: Winning Dayong Gao Young Investigator Award Cryobiology Society[79]
  • Receiving several Razi Research Awards on Medical Science hosted by the Iran Ministry of Health and Medical Education

See also

Notes
  1. Miremadi, Tahereh (2013). "Chapter 7: Biotechnology in Iran: A study of the structure and functions of the technology innovation system". In Soofi, Abdol S.; Ghazinoory, Sepehr (eds.). Science and innovations in Iran: development, progress, and challenges. New York: Palgrave Macmillan. pp. 139–158. ISBN 9781137030092.
  2. "Memorial - Royan Institute". www.royaninstitute.org. Retrieved 2017-12-09.
  3. "Countries Where Stem Cell Research Is Most Popular". August 2017.
  4. "Iran in the forefront when it comes to stem cell research".
  5. https://ibb.ut.ac.ir/
  6. https://celljournal.org/
  7. https://royanstemcell.ir/
  8. "Royan Stem Cell – Royan institute for Stem Cell Biology and Technology (RI-SCBT)".
  9. "Royan Stem Cell – Royan institute for Stem Cell Biology and Technology (RI-SCBT)".
  10. "Royan Stem Cell – Royan institute for Stem Cell Biology and Technology (RI-SCBT)".
  11. "Royan Stem Cell – Royan institute for Stem Cell Biology and Technology (RI-SCBT)".
  12. Aneesh Raman (2006-11-17). "Iran in the forefront when it comes to stem cell research". Edition.cnn.com. Retrieved 2012-12-11.
  13. "Reproductive Biomedicine - Royan Institute". www.royaninstitute.org.
  14. https://en.royan-edu.ir/
  15. "News, sport and opinion from the Guardian's US edition | the Guardian".
  16. https://www.sciencedirect.com/
  17. https://www.royan.org/
  18. https://www.sciencedirect.com/
  19. https://www.sid.ir/FileServer/JE/107320080208
  20. https://connect.isti.ir/media/associations/Introduction/royan.pdf
  21. https://connect.isti.ir/media/associations/Introduction/royan.pdf
  22. https://www.ncbi.nlm.nih.gov/
  23. https://royanstemcell.ir/
  24. https://www.sciencedirect.com/
  25. https://www.frontiersin.org/
  26. https://www.sid.ir/FileServer/JE/82320190402
  27. https://www.rsct.ir/
  28. https://www.jstor.org/
  29. Sheikhi, Marjohn (30 September 2015). "Birth anniversary of Royana; Iran's 1st cloned sheep". Mehr News Agency. Retrieved 2017-12-09.
  30. https://www.sid.ir/FileServer/JE/82320083905
  31. https://www.ncbi.nlm.nih.gov/
  32. https://stemcellres.biomedcentral.com/
  33. https://royanipd.com/
  34. https://www.nbcnews.com/
  35. "Iran produces another transgenic goat".
  36. https://www.sid.ir/FileServer/JE/107320110407
  37. https://www.royan.org/
  38. https://parentsguidecordblood.org/
  39. https://www.sid.ir/fileserver/je/57006820130209
  40. https://connect.isti.ir/media/associations/Introduction/royan.pdf
  41. Dehghan, Saeed Kamali (5 August 2015). "Scientists in Iran clone endangered mouflon – born to domestic sheep". The Guardian. Retrieved 2017-12-09.
  42. https://www.sciencedirect.com/science/article/am/pii/S0303720718300881
  43. "ZFIN Lab: Royan Zebrafish Core Facility".
  44. Abtahi, N. S.; Ebrahimi, B.; Fathi, R.; Khodaverdi, S.; Mehdizadeh Kashi, A.; Valojerdi, M. R. (2016). "An Introduction to the Royan Human Ovarian Tissue Bank". International Journal of Fertility & Sterility. 10 (2): 261–263. PMC 4948080. PMID 27441061.
  45. "Faculty of Basic Sciences and Medical Technology".
  46. https://www.royan.org/
  47. https://www.royanatmp.com/wp-content/uploads/2017/10/Regulations-on-Biological-products_March-2018.pdf
  48. Agarwal, Ashok; Panner Selvam, Manesh Kumar; Baskaran, Saradha; Finelli, Renata; Leisegang, Kristian; Barbăroșie, Cătălina; Pushparaj, Peter Natesan; Robert, Kathy Amy; Ambar, Rafael; Iovine, Concetta; Durairajanayagam, Damayanthi; Henkel, Ralf (2021). "A scientometric analysis of research publications on male infertility and assisted reproductive technology". Andrologia. 53 (1): e13842. doi:10.1111/and.13842. PMID 33236365. S2CID 227168950.
  49. https://clinicaltrials.gov/
  50. https://www.ijfs.ir/article_45880_e4188ad3309fbba12ec5adfb6e77d3d5.pdf
  51. https://connect.isti.ir/media/associations/Introduction/royan.pdf
  52. https://www.ncbi.nlm.nih.gov/
  53. https://hpscreg.eu/cell-line/RIe001-A
  54. Baharvand, Hossein; Ashtiani, Saeid Kazemi; Taee, Adeleh; Massumi, Mohammad; Valojerdi, Mojtaba R.; Yazdi, Poopak E.; Moradi, Shabnam Z.; Farrokhi, Ali (2006). "Generation of new human embryonic stem cell lines with diploid and triploid karyotypes". Development, Growth and Differentiation. 48 (2): 117–128. doi:10.1111/j.1440-169X.2006.00851.x. PMID 16512855. S2CID 33331693.
  55. CULTURE_CONDITION_DIFFERENCE_FOR_ESTABLISHMENT_OF_NEW_EMBRYONIC_STEM_CELL_LINES.pdf
  56. Best poster award in Stem Cell congress, India, 2005
  57. https://r-ins.ir/cmsen/index.php?option=com_content&task=view&id=29&Itemid=40
  58. Best researcher in Razi medical sciences award 2006
  59. https://connect.isti.ir/media/associations/Introduction/royan.pdf
  60. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.royanaward.com/21thAwardBook.pdf
  61. ijrm-v19n5p1-en%20(1).pdf
  62. https://www.scopus.com/
  63. https://www.ijfs.ir/
  64. https://www.celljournal.org/
  65. "About Us".
  66. https://eprints.bmsu.ac.ir/3833/1/Therapeutic%20application%20of%20multipotent%20stem%20cells..pdf
  67. Taei, Adeleh; Gourabi, Hamid; Seifinejad, Ali; Totonchi, Mehdi; Shahbazi, Ebrahim; Valojerdi, Mojtaba Rezazadeh; Eftekhari, Poopak; Karimian, Leila; Baharvand, Hossein (2010). "Derivation of new human embryonic stem cell lines from preimplantation genetic screening and diagnosis-analyzed embryos". In Vitro Cellular & Developmental Biology. Animal. 46 (3/4): 395–402. doi:10.1007/s11626-010-9293-3. JSTOR 40663820. PMID 20177993. S2CID 44339595.
  68. "RIe007-A · Cell Line · hPSCreg".
  69. Radpour, R.; Gourabi, H.; Gilani, M. A. S.; Dizaj, A. V. (2007). "Molecular Study of (TG)m(T)n Polymorphisms in Iranian Males with Congenital Bilateral Absence of the Vas Deferens". Journal of Andrology. 28 (4): 541–547. doi:10.2164/jandrol.106.002337. PMID 17314234.
  70. https://www.royanaward.com/
  71. https://en.royan-edu.ir/
  72. "Iran scientist wins ISESCO 2010 Prizes for Science, Technology". 19 June 2010.
  73. "Scientists from Burkina Faso, Iran and Peru receive UNESCO-Equatorial Guinea International Prize for Research in the Life Sciences". UNESCO. 2014-09-15.
  74. Baharvand, H. (30 March 2015). Stem-Cell Nanoengineering. ISBN 9781118540619.
  75. "TWAS elects 36 new Fellows".
  76. "Call for participation in the 32nd Khwarizmi International Award Call for Participation | International and Scientific Cooperation Center".
  77. "Significance of honoring scientists discussed at unveiling ceremony of 2019 Mustafa(pbuh) Prize laureates' busts".
  78. https://pubmed.ncbi.nlm.nih.gov/
  79. "Dayong Gao Young Investigator Award".

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