Neuron derived neurotrophic factor

NDNF
Identifiers
Aliases	NDNF, C4orf31, NORD, neuron-derived neurotrophic factor, neuron derived neurotrophic factor, HH25
External IDs	OMIM: 616506 MGI: 1915419 HomoloGene: 11593 GeneCards: NDNF
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	121,073,021 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	65,689,310 bp[2]
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; visceral pleura; ; lower lobe of lung; ; periodontal fiber; ; right lung; ; bronchial epithelial cell; ; tibia; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	calvaria; ; left lung lobe; ; right lung; ; right lung lobe; ; renal corpuscle; ; iris; ; otolith organ; ; maxillary prominence; ; utricle; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosaminoglycan binding; heparin binding;
Cellular component	extracellular matrix; intracellular anatomical structure; extracellular region;
Biological process	negative regulation of neuron apoptotic process; negative regulation of endothelial cell apoptotic process; response to ischemia; neuron migration; cellular response to hypoxia; angiogenesis; nervous system development; nitric oxide mediated signal transduction; positive regulation of neuron projection development; positive regulation of cell-substrate adhesion; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; extracellular matrix organization; vascular wound healing;
	Sources:Amigo / QuickGO
Orthologs
	79625
	68169
	ENSG00000173376
	ENSMUSG00000049001
	Q8TB73
	Q8C119
	NM_024574
	NM_172399
	NP_078850
	NP_765987
	Wikidata
View/Edit Human	View/Edit Mouse

Neuron derived neurotrophic factor is a protein that in humans is encoded by the NDNF gene. [5]

References

GRCh38: Ensembl release 89: ENSG00000173376 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049001 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Neuron derived neurotrophic factor". Retrieved 2017-06-27.

Utine GE, Aktas D (2006). "Mosaicism for terminal deletion of 4q". Genet. Couns. 17 (2): 205–9. PMID 16970039.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173376 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049001 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Neuron derived neurotrophic factor". Retrieved 2017-06-27.

Neuron derived neurotrophic factor

References

Further reading