Sodium-dependent phosphate transport protein 2B
Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.[5][6][7]
| SLC34A2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SLC34A2, NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604217 MGI: 1342284 HomoloGene: 2297 GeneCards: SLC34A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Clinical significance
Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.[8]
References
- GRCh38: Ensembl release 89: ENSG00000157765 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000029188 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (Jun 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochem Biophys Res Commun. 258 (3): 578–82. doi:10.1006/bbrc.1999.0666. PMID 10329428.
- Xu H, Bai L, Collins JF, Ghishan FK (Feb 2000). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–4. doi:10.1006/geno.1999.6009. PMID 10610722.
- "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
- Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G (2008). "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immun. 8: 3. PMC 2935786. PMID 18251464.
Further reading
- Xu H, Collins JF, Bai L, et al. (2001). "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". Am. J. Physiol., Cell Physiol. 280 (3): C628–36. doi:10.1152/ajpcell.2001.280.3.C628. PMID 11171583. S2CID 7439508.
- Segawa H, Kaneko I, Takahashi A, et al. (2002). "Growth-related renal type II Na/Pi cotransporter". J. Biol. Chem. 277 (22): 19665–72. doi:10.1074/jbc.M200943200. PMID 11880379.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Xu H, Uno JK, Inouye M, et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81. doi:10.1152/ajpgi.00396.2004. PMID 15458926. S2CID 14194207.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Corut A, Senyigit A, Ugur SA, et al. (2006). "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis". Am. J. Hum. Genet. 79 (4): 650–6. doi:10.1086/508263. PMC 1592565. PMID 16960801.
- Huqun, Izumi S, Miyazawa H, et al. (2007). "Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis". Am. J. Respir. Crit. Care Med. 175 (3): 263–8. doi:10.1164/rccm.200609-1274OC. PMID 17095743.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.