Molecular configuration

The molecular configuration of a molecule is the permanent geometry that results from the spatial arrangement of its bonds.[1] The ability of the same set of atoms to form two or more molecules with different configurations is stereoisomerism. This is distinct from constitutional isomerism which arises from atoms being connected in a different order.

Used as drugs, compounds with different configuration normally have different physiological activity, including the desired pharmacological effect, the toxicology and the metabolism.[2]

See also

References
  1. IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version: (2006–) "configuration (stereochemical)". doi:10.1351/goldbook
  2. Everhardus Ariëns: Stereochemistry, the basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology, European Journal of Clinical Pharmacology 26 (1984) 663-668, doi:10.1007/BF00541922.
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