Marc K. Jenkins

Marc K. Jenkins is a Regents Professor and Director of the Center for Immunology at the University of Minnesota. He is a member of the National Academy of Sciences.

Marc K. Jenkins
Born
Minnesota, USA
EducationB.S. University of Minnesota 1980

Ph.D. Northwestern University 1985

Postdoctoral Fellowship, National Institutes of Health 1985-1988
EmployerUniversity of Minnesota
SpouseKaren Jenkins

Education and career

Jenkins received his B.S. in Microbiology from the University of Minnesota in 1980. He completed his Ph.D. in Microbiology and Immunology in 1985 from Northwestern University and then conducted postdoctoral training in the Laboratory of Immunology at the National Institutes of Health from 1985-1988. In 1988, Jenkins joined the Microbiology Department at the University of Minnesota where he is now a Regents Professor and Director of the UMN Center for Immunology.[1] He conducts immunology research on antigen-specific helper T cells and B cells. Along with his work at the University of Minnesota, he has also been an active member of the American Association of Immunologists (AAI) where he served as President from 2013-2014.[2]

Research achievements

Jenkins's research has focused on CD4+ T cells, which are cells of the immune system that control infections and cancers. His group at the University of Minnesota was one of the first to discover that CD28 provides the second signal to human CD4 + T cells.[3] His group also showed that antigen-specific CD4 + T cells first become activated in the central part of lymph nodes,[4] then migrate to B cell-rich follicles and non-lymphoid organs,[5] and documented the cellular changes that produce immune memory.[6][7]

His current studies seek to understand the mechanisms of CD4 + T cell activation, memory cell formation, and immune protection, with the ultimate goal of using basic immunology discoveries to make better vaccines and prevent unwanted immune responses such as transplant rejection and autoimmunity.

Community service

Jenkins has lived in Richfield, MN for the last 35 years. He worked on behalf of the Richfield Public Schools and was elected to the District 280 school board in 2004.[8] In 2020, he received the Key to the City of Richfield in part for his service to the community.

Awards and honors

References
  1. "Marc K. Jenkins, PhD". Center for Immunology - University of Minnesota. Retrieved 2022-07-02.
  2. "AAI Past Presidents and Officers". The American Association of Immunologists. 2023.
  3. Jenkins, M. K.; Taylor, P. S.; Norton, S. D.; Urdahl, K. B. (1991-10-15). "CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells". Journal of Immunology. 147 (8): 2461–2466. ISSN 0022-1767. PMID 1717561.
  4. Itano, Andrea A.; McSorley, Stephen J.; Reinhardt, R. Lee; Ehst, Benjamin D.; Ingulli, Elizabeth; Rudensky, Alexander Y.; Jenkins, Marc K. (July 2003). "Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity". Immunity. 19 (1): 47–57. doi:10.1016/s1074-7613(03)00175-4. ISSN 1074-7613. PMID 12871638.
  5. Garside, P.; Ingulli, E.; Merica, R. R.; Johnson, J. G.; Noelle, R. J.; Jenkins, M. K. (1998-07-03). "Visualization of specific B and T lymphocyte interactions in the lymph node". Science. 281 (5373): 96–99. doi:10.1126/science.281.5373.96. ISSN 0036-8075. PMID 9651253.
  6. Pepper, Marion; Pagán, Antonio J.; Igyártó, Botond Z.; Taylor, Justin J.; Jenkins, Marc K. (2011-10-28). "Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells". Immunity. 35 (4): 583–595. doi:10.1016/j.immuni.2011.09.009. ISSN 1097-4180. PMC 3208313. PMID 22018468.
  7. Reinhardt, R. L.; Khoruts, A.; Merica, R.; Zell, T.; Jenkins, M. K. (2001-03-01). "Visualizing the generation of memory CD4 T cells in the whole body". Nature. 410 (6824): 101–105. doi:10.1038/35065111. ISSN 0028-0836. PMID 11242050.
  8. ray.rivard@apgecm.com, Raymond T. Rivard. "Richfield resident elected to National Academy of Sciences". hometownsource.com. Retrieved 2023-01-02.
  9. "Marc K. Jenkins". www.nasonline.org. Retrieved 2023-01-02.
  10. "AAI Lifetime Achievement Award Past Recipients". The American Association of Immunologists. 2023.
  11. "Current Regents Professors | University Awards & Honors". uawards.umn.edu. Retrieved 2023-01-02.
  12. "AAI Excellence in Mentoring Award Past Recipients". The American Association of Immunologists. 2023.
  13. "Pew Directory of Scholars- Marc K. Jenkins, PH.D". PEW Trusts. 2023.
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