Ana Domingos

Ana I. Domingos is a Portuguese neuroscientist specialising in the reduction of obesity independently of food intake. She is an Associate Professor of Neuroscience at the Department of Physiology, Anatomy and Genetics of the University of Oxford in the United Kingdom, as well as a Teaching Fellow at Lady Margaret Hall, Oxford.[1]

Ana Domingos
Born
Ana Domingos

Portugal
OccupationNeuroscientist
Known forStudies on obesity
Websitehttps://domingoslabobesity.weebly.com/; https://www.neuroscience.ox.ac.uk/research-directory/ana-domingos

Training

Between 1995 and 1999, Domingos studied mathematics up to MSc level at the University of Lisbon. She then studied for a PhD in neurobiology at the Rockefeller University in New York City, supervised by Leslie B. Vosshall.[1][2][3]

Career

Between 2006 and 2013, Domingos did post-doctoral work with Jeffrey M. Friedman at the Rockefeller University. She then returned to Portugal to work at the Obesity Laboratory of the Instituto Gulbenkian de Ciência in Oeiras near the Portuguese capital, Lisbon. In 2018 she moved to Oxford in the UK, with a research award from the Howard Hughes Medical Institute, to work at the Department of Physiology, Anatomy and Genetics of the University of Oxford, where she heads the laboratory that bears her name. She is also funded by the Wellcome Trust and the European Research Council.[1][2][3][4]

Her laboratory researches neuroimmune mechanisms underlying obesity. It has identified sympathetic neuron-associated macrophages (SAMs) that import and metabolize norepinephrine, which can lead to fat mass reduction. In a collaborative effort with the University of Cambridge, Domingos has developed a new class of anti-obesity compounds that could potentially avoid the harmful side effects of traditional treatments.[1][2][5][6]

Publications

Domingos has published widely in peer-reviewed journals. A selection of her articles for which she has been the sole author or lead article follows.[3][7] In addition, she is a member of the Advisory Board of the journal, Cell Metabolism.[8]

  • AI Domingos, J Vaynshteyn, HU Voss, X Ren, V Gradinaru, F Zang, et al. Leptin regulates the reward value of nutrient. Nature neuroscience 14 (12), 1562-1568
  • AI Domingos, A Sordillo, MO Dietrich, ZW Liu, LA Tellez, J Vaynshteyn, et al. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. Elife 2, e01462
  • AI Domingos, J Vaynshteyn, A Sordillo, JM Friedman. The reward value of sucrose in leptin-deficient obese mice. Molecular metabolism 3 (1), 73-80 279
  • AI Domingos. Leptin: a missing piece in the immunometabolism puzzle. Nature Reviews Immunology 20 (1), 3-3
  • A Domingos. Lean on Leptin or Lean for Sugar. J Obes Wt Loss Ther 3 (166), 2

References
  1. "Ana Domingos". VIB. Retrieved 6 May 2021.
  2. "Ana Domingos". RTP Afinidades. Retrieved 6 May 2021.
  3. "Ana I Domingos". ORCid. Retrieved 6 May 2021.
  4. "Cientistas descobrem que sistema imunitário contribui para obesidade". Correio da Manhã. Retrieved 6 May 2021.
  5. "Domingos, Ana". ISNI. Retrieved 6 May 2021.
  6. "Obesity". Gulbenkian. Retrieved 6 May 2021.
  7. "Ana Domingos". Google Scholar. Retrieved 6 May 2021.
  8. "Ana Domingos joins the Cell Metabolism Advisory Board". Department of Physiology, Anatomy and Genetics. Retrieved 6 May 2021.
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