ADAM20

ADAM20
Identifiers
Aliases	ADAM20, ADAM metallopeptidase domain 20
External IDs	OMIM: 603712 MGI: 3045694 HomoloGene: 128364 GeneCards: ADAM20
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	70,535,015 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	41,280,074 bp[2]
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; corpus callosum; ; cervix; ; cerebellar cortex; ; cerebellar hemisphere; ; liver; ; prefrontal cortex; ; gastrocnemius muscle; ; popliteal artery;
	Top expressed in
	spermatid; ; testicle; ; spermatocyte; ; pancreas; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	proteolysis; single fertilization; binding of sperm to zona pellucida;
	Sources:Amigo / QuickGO
Orthologs
	8748
	546055
	ENSG00000134007
	ENSMUSG00000054033
	O43506
	Q7M762
	NM_003814
	NM_001025380
	NP_003805
	NP_001020551
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 20 is an enzyme that in humans is encoded by the ADAM20 gene. It is a membrane disintegrin-metalloprotease that belongs to the ADAM family. It is exclusively expressed in Testes and is similar to sperm cell-specific fertilins -alpha and -beta.

Its cDNA was mapped, and was found to be tightly linked to marker SHGC-36001 on chromosome 14q24.1. ADAM 20 may be the functional equivalent of fertilin-alpha in humans.[5]

References

GRCh38: Ensembl release 89: ENSG00000134007 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000054033 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hooft van Huijsduijnen R (January 1998). "ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha". Gene. 206 (2): 273–82. doi:10.1016/s0378-1119(97)00597-0. PMID 9469942.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134007 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054033 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Hooft van Huijsduijnen R (January 1998). "ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha". Gene. 206 (2): 273–82. doi:10.1016/s0378-1119(97)00597-0. PMID 9469942.